apalutamide will decrease the extent or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with drugs which are CYP2C19 substrates may lead to decrease exposure to those remedies.diazepam will raise the degree or effect of ruxolitinib by i